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Common use Daliresp is used to reduce the risk of COPD exacerbations in patients with severe chronic obstructive pulmonary disease associated with chronic bronchitis. Roflumilast is a phosphodiesterase-4 (PDE4) inhibitor that works by decreasing inflammation in the lungs. Dosage and direction Take Daliresp orally once daily, with or without food, as prescribed by your doctor. Swallow the tablet whole with water, and take it at the same time each day for best results. Precautions Inform your doctor if you have liver disease, depression, or a history of mental health conditions. Weight loss and mood changes may occur during treatment, and regular monitoring is recommended. Contraindications Do not use Daliresp if you have moderate to severe liver impairment. It is not intended for use during acute COPD attacks or in people allergic to Roflumilast. Possible side effect Common side effects include diarrhea, nausea, weight loss, headache, and insomnia. Rare but serious side effects may involve mood changes, depression, or suicidal thoughts. Drug interaction Roflumilast may interact with CYP3A4 inhibitors or inducers, such as rifampin, ketoconazole, and certain anticonvulsants. Always inform your doctor about all medications and supplements you are taking. Missed dose If you miss a dose, take it as soon as you remember. If it's nearly time for your next dose, skip the missed one—do not double up. Overdose Symptoms of overdose may include severe nausea, vomiting, or mental/mood changes. In such cases, seek emergency medical assistance immediately. Storage Store Daliresp at room temperature, away from heat and moisture. Keep the tablets in their original container and out of reach of children. Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.